Akeso, Inc. Enjoys Bright Prospects as Favored by the Capital Market
- 2020年04月24日 19:37:00
- テクノロジー
- JCN Newswire
Efficient R&D Platform and Strong R&D Strength
The Company is dedicated to finding solutions to treat tumors and immunological diseases. It is generally known that it takes years to develop a new drug. However, the Company has over 20 drug development programs developed in-house though it has been established for only eight years. These programs include 12 antibodies in clinical-stage development, six bi-specific antibodies (two of which are at the clinical stage), and four antibodies with IND approvals from the Food and Drug Administration (FDA). Its product pipelines cover several major diseases, such as tumors, immunological diseases, and cardiovascular diseases. It is worth mentioning that the Company has developed all its programs in-house. In November 2015, the Company became the first China-based biotech company to out-license a fully internally discovered monoclonal antibody to a world-leading pharmaceutical company as it out-licensed its CTLA-4 monoclonal antibody drug candidate (AK107) to Merck for a total consideration of up to USD200 million.
The Company's strong R&D capability is indispensable from its end-to-end ACE Platform that possesses comprehensive, the most cutting-edge functionalities in developing therapeutic antibodies. The ACE Platform encompasses drug development and manufacturing and enables seamless technology transfer from drug discovery and CMC to manufacturing. Moreover, it holds strong internal manufacturing capacity that is compliant with GMP standards regulated by the NMPA, FDA and EMA. All drugs in the clinical stage are produced in the Company's proprietary facilities in line with GMP standards.
Prominent Advantages of Core Products, Favored by the Capital Market
The key to biopharmaceutical success lies in R&D strength and efficiency. The player who takes the lead to develop a drug and obtain approval for launch, and who can prove commercialization capabilities will gain competitive edges.
The Company has developed industry-leading drugs with the ACE Platform including its core products: PD-1/CTLA-4 bi-specific antibody (AK104) and PD-1 monoclonal antibody drug, Penpulimab (AK105). Its products also encompass AK101, a promising monoclonal antibody against autoimmune diseases, and AK102 that has high potential to become the first cardiovascular drug candidate against PCSK9 developed in China.
The Company has led the world in terms of the R&D of bi-specific antibodies. Bi-specific antibodies are deemed as a second-generation antibody therapy against tumors. With respect to the research on bi-specific antibodies, the Company possesses the unique bifunctional antibody technology, Tetrabody, making it one of the few bi-specific antibody platforms verified in both manufacturing and clinical stage. According to clinical observation, compared with the combined therapy of Nivolumab and Ipilimumab, AK104 has demonstrated better safety and efficacy. As of September 30, 2019, over 90 bi-specific antibodies were undergoing clinic trial. Nevertheless, no PD-(L)-based bi-specific antibodies had been approved for market launch. AK104 is the world's first bi-specific antibody drug that is in the clinical trial stage. It is expected that the first new drug application (NDA) of AK104 of the Company for treating cervical cancer will result in first-mover advantage.
AK105 of the Company is a monoclonal antibody currently in late-stage clinical development. PD-1 monoclonal antibody drugs are experiencing fierce competition, as six PD-1 drugs have been launched in China. Despite the extensively competitive market, AK105 is still favored for its strong efficacy and high safety. Therefore, Sino Biopharmaceutical Limited, a HK-listed pharmaceutical leader, has cooperated with the Company to jointly develop and commercialize AK105. AK105 of the Company is the only PD-1 antibody that Sino Biopharm can use to develop PD-1-based monotherapy or combination therapy, which evidences the great commercial potential of AK105. After the new drug is launched, the wide online sale channels and immense commercial capability of Sino Biopharmaceutical Limited will be utilized by the Company to maximize the commercial value of AK105.
Thanks to its strong R&D strength and commercialization capabilities, the Company has been favored by the capital market. Through Series D financing in November last year, the Company raised USD126 million in total, with the leading investor being Sino Biopharmaceutical Limited. Medical funds like Lake Bleu Capital, OrbiMed, and AIHC Capital participated in the financing. The Company's valuation reached USD836 million after Series D financing and became nearly 18 times as high as that after Series A financing of RMB330 million in just four years. Especially, Shenzhen Capital Group Co., Ltd. (SCGC), a leading venture capital firm in China that was co-founded by the Shenzhen Municipal Government and a group of private partners, participated in every series of financing. Relevant funds under K. Wah Group became a shareholder of Akeso in the series of financing before the IPO. This also means that K. Wah Group has set foot in the healthcare sector. Investment from famous capital holders reflect Akeso's bright future.
Copyright 2020 JCN Newswire. All rights reserved. www.jcnnewswire.com
神田正輝「旅サラダ」生放送で松下奈緒に”敗北宣言”「もうかなわなくなってきた」
人気お天気キャスターが「報ステ」卒業 今後は「経験生かしながら新しいことにも挑戦」
選挙ポスター、露出政見放送…騒動相次ぐ都知事選に高知東生「選挙改革を本気で考えて」
バルサ、ヤマルへのパリSG史上最高の移籍金412億円ビッグオファー拒否 ネイマール超え
神田正輝、“カミカミ”猛反省の52歳女優に「生放送だからそれがいい」
助けてくれた日本の漁師はどこに…北方領土、知られざる日露の物語
川口春奈、”美が増しすぎてませんか?”『FENDI』インナーカラー×ピンクニット
FAMIMA CAFEのアイスコーヒー・ブレンドがもっと美味しくなりました!
何があった!?「エアコン」が想定外の壊れ具合!投稿者に話を聞いた
「VARON オールインワンセラム」が2023年メンズスキンケアカテゴリー売上No.1の快挙
何があった!?「エアコン」が想定外の壊れ具合!投稿者に話を聞いた
ひまそらあかねを無視するマスコミ、岩下の新生姜社長が名前を出すだけで「不買運動」が叫ばれる事態に
丸亀製麺の「丸亀うどーなつ」が販売開始で完売店舗続出!過去の「うどんで作ったドーナッツ」と比較すると……
【ネタバレ?】史実で見るキングダムの今後の展開まとめ〜中華統一までの全体像
玉置浩二の妻、青田典子(53)の現在がとんでもない事になっていると話題に
「エロい」42歳山川恵里佳、白ビキニのオフショ動画4連発!20年ぶりグラビア復帰「最ッ高」
中国・日本人母子刺傷 止めに入ったバス案内係の中国人女性死亡
株主優待の桐谷さん「アダルトサイトを見てたらウィルス感染」正直投稿 修復のお礼はやはり…
松本人志告発女性からの性被害否定報道に小籔千豊「ハッピーな情報かなと、思ってしまうけど…」
ひろゆき氏、立花孝志氏に言及「マジで捕まえたほうがいい」三浦春馬さんポスターに抗議受け謝罪
何があった!?「エアコン」が想定外の壊れ具合!投稿者に話を聞いた
玉置浩二の妻、青田典子(53)の現在がとんでもない事になっていると話題に
【ネタバレ?】史実で見るキングダムの今後の展開まとめ〜中華統一までの全体像
イケメンだから許される!堀北真希と山本耕史の「馴れ初め」が映画化希望するレベル
ガーシーが綾野剛のLINE公開でネット騒然「ショック」「すごいエンタメ」
「愛が生まれた日」藤谷美和子(56)の現在がヤバい!?徘徊生活を送っていた過去も明らかに。
ユーチューバーもこう氏、元彼女・成海瑠奈について赤裸々告白
都知事選掲示板にヌードポスター ひろゆき氏「世も末」 SNSで批判噴出
柏原崇(45)現在を調べてみた結果、相変わらずかっこよすぎた!
岡本夏生(56)、1600日ぶりにブログを更新した現在が衝撃
神田正輝「旅サラダ」生放送で松下奈緒に”敗北宣言”「もうかなわなくなってきた」
人気お天気キャスターが「報ステ」卒業 今後は「経験生かしながら新しいことにも挑戦」
選挙ポスター、露出政見放送…騒動相次ぐ都知事選に高知東生「選挙改革を本気で考えて」
バルサ、ヤマルへのパリSG史上最高の移籍金412億円ビッグオファー拒否 ネイマール超え
神田正輝、“カミカミ”猛反省の52歳女優に「生放送だからそれがいい」
助けてくれた日本の漁師はどこに…北方領土、知られざる日露の物語
川口春奈、”美が増しすぎてませんか?”『FENDI』インナーカラー×ピンクニット
FAMIMA CAFEのアイスコーヒー・ブレンドがもっと美味しくなりました!
何があった!?「エアコン」が想定外の壊れ具合!投稿者に話を聞いた
「VARON オールインワンセラム」が2023年メンズスキンケアカテゴリー売上No.1の快挙